Controlled delivery of protoporphyrin IX precursors for photodynamic therapy of tumors using water soluble polymer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10500950" target="_blank" >RIV/00216208:11310/25:10500950 - isvavai.cz</a>
Result on the web
<a href="https://www.epf2025.org/" target="_blank" >https://www.epf2025.org/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Controlled delivery of protoporphyrin IX precursors for photodynamic therapy of tumors using water soluble polymer
Original language description
Among anticancer therapies, photodynamic therapy (PDT) is an advantageous approach thanks to its noninvasive character and low side effects. Its principle is based on using a photosensitizer, light and presence of oxygen to generate singlet oxygen leading to cell death. However, common photosensitizers still lack tumor targeting properties as well as prolonged blood circulation. An example of such photosensitizer is protoporphyrin IX (PPIX), which is often administered not itself, but in form of a prodrug, 5-aminolevulinic acid (5-ALA), which is metabolized to PPIX inside the cells. To overcome the poor pharmacokinetics of 5-ALA, we designed new nanomedicines based on covalently conjugated 5-ALA or its hexylester (HAL) to a water soluble copolymer of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA). Water soluble polymer conjugates based on PHPMA have been used successfully for the delivery of many anticancer agents (2) relying on the enhanced permeability and retention (EPR) effect enabling high accumulation of the polymer conjugate in the tumor tissue. Herein, we present the synthesis of the nanomedicines by controlled radical polymerization with subsequent conjugation of 5-ALA/HAL via a pH sensitive hydrazone bond. Such nanomedicines present desired physico-chemical properties, pH sensitive release of 5-ALA/HAL and superior anticancer efficacy in vivo after irradiation.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů