Polymeric nanocarriers of a monosubstituted tetraphenylporphyrin sensitizer intended for photodynamic therapy and tumor imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00642839" target="_blank" >RIV/61389013:_____/25:00642839 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/25:00642839
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c07910" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c07910</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.5c07910" target="_blank" >10.1021/acsomega.5c07910</a>
Alternative languages
Result language
angličtina
Original language name
Polymeric nanocarriers of a monosubstituted tetraphenylporphyrin sensitizer intended for photodynamic therapy and tumor imaging
Original language description
To effectively combat advanced cancers, next-generation nanomedicines should combine both therapeutic and diagnostic functions. In this study, we developed stimulus-responsive theranostics systems based on micellar nanostructures that deliver derivatives of tetraphenylporphyrins (TPP) bound via tumor microenvironment-sensitive hydrazone bonds. These nanomedicines are engineered using a micelle-forming polymer-TPP conjugate, enabling the pH-sensitive activation of both photodynamic therapy (PDT) and fluorescence. Two pH-sensitive and one stable polymer-TPP conjugates were synthesized and characterized by size exclusion chromatography and TPP release rates. Micelle stability was evaluated using UV/vis spectroscopy, while fluorescence and singlet oxygen production were measured to determine their theranostics potential. Femtosecond transient absorption and time-correlated single photon counting techniques were employed for the photophysical evaluation of micellar systems. Compared to polymer conjugates where TPP is linked through nondegradable amide bonds, the pH-sensitive systems exhibit superior physicochemical properties. These micellar conjugates are highly stable, allowing prolonged circulation in the body while remaining in an “off” state, where fluorescence and singlet oxygen production are minimized. Overall, the hydrazone-linked conjugates display favorable properties that make them strong candidates for future anticancer theranostic applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
2470-1343
Volume of the periodical
10
Issue of the periodical within the volume
46
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
56201-56216
UT code for WoS article
001611279600001
EID of the result in the Scopus database
2-s2.0-105022749655