Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00575824" target="_blank" >RIV/61389013:_____/23:00575824 - isvavai.cz</a>
Result on the web
<a href="https://www.thno.org/v13p4952" target="_blank" >https://www.thno.org/v13p4952</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7150/thno.86211" target="_blank" >10.7150/thno.86211</a>
Alternative languages
Result language
angličtina
Original language name
Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging
Original language description
Efficient theranostic strategies concurrently bring and use both the therapeutic and diagnostic features, serving as a cutting-edge tool to combat advanced cancers. Here, we develop stimuli-sensitive theranostics consisting of tailored copolymers forming micellar conjugates carrying pyropheophorbide-a (PyF) attached by pH-sensitive hydrazone bonds, thus enabling the tumor microenvironment-sensitive activation of the photodynamic therapy (PDT) effect, fluorescence or phosphorescence. The nanomedicines show superior anti-tumor PDT efficacy and huge tumor-imaging potential, while reducing their accumulation, and potentially side effects, in the liver and spleen. The developed theranostics exhibit clear selective tumor accumulation at high levels in the mouse sarcoma S180 tumor model with almost no PyF found in the healthy tissues after 48 h. Once in the tumor, illumination at λexc = 420 nm reaches the therapeutic effect due to the 1O2 generation. Indeed, an almost complete inhibition of tumor growth is observed up to 18 days after the treatment. The clear benefit of the specific PyF release and activation in the acidic tumor environment for the targeted delivery and tissue distribution dynamics was proved. Conjugates carrying pyropheophorbide-a (PyF) attached by pH-sensitive hydrazone bonds showed their excellent antitumor PDT effect and its applicability as advanced theranostics at very low dose of PyF.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Theranostics
ISSN
1838-7640
e-ISSN
1838-7640
Volume of the periodical
13
Issue of the periodical within the volume
14
Country of publishing house
AU - AUSTRALIA
Number of pages
22
Pages from-to
4952-4973
UT code for WoS article
001085028000015
EID of the result in the Scopus database
2-s2.0-85172829315