Midgut and stomodeal valve attachment of Leishmania in sand flies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10503671" target="_blank" >RIV/00216208:11310/25:10503671 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nxikGeMf_T" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nxikGeMf_T</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pt.2025.06.017" target="_blank" >10.1016/j.pt.2025.06.017</a>
Alternative languages
Result language
angličtina
Original language name
Midgut and stomodeal valve attachment of Leishmania in sand flies
Original language description
Leishmania development in sand flies involves critical attachment steps to the midgut epithelium and the stomodeal valve, mediated by parasite- and vector-derived molecules. Initial midgut attachment prevents parasite loss during defe-cation and determines vector competence. In specific vectors like Phlebotomus papatasi, attachment involves galectins and Leishmania lipophosphoglycan, while in permissive species like Lutzomyia longipalpis, mucin adhesion domi-nates. Later, promastigotes adhere to the stomodeal valve, forming adhesion plaques, which in combination with the promastigote secretory gel (PSG) blocks the gut and promotes transmission. Recent studies identified three flagellar pro-teins (KIAP1-3) crucial for plaque formation. Knockouts of KIAPs prevented sto-modeal valve colonization and PSG production, likely impacting parasite transmission. Thus, KIAPs are essential for late-stage Leishmania development in sand flies
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10600 - Biological sciences
Result continuities
Project
<a href="/en/project/GA25-15318S" target="_blank" >GA25-15318S: Sand fly-Leishmania interaction: Two types of attachment as critical steps in parasite life cycle.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Parasitology
ISSN
1471-4922
e-ISSN
1471-5007
Volume of the periodical
41
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
769-779
UT code for WoS article
001570781800009
EID of the result in the Scopus database
2-s2.0-105011274085