Similarity Search and Posttranslational Modifications in Tandem Mass Spectra

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F10%3A10057171" target="_blank" >RIV/00216208:11320/10:10057171 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Similarity Search and Posttranslational Modifications in Tandem Mass Spectra
Original language description
Tandem mass spectrometry is a fast and modern method for determining protein and peptide sequences from an "in vitro" sample. A mass spectrometer outputs mass spectra, which are utilized for sequences identification. The successful methods for mass spectra interpretation are based on search in databases of already known or predicted protein sequences. Since the amount of protein sequences in the databases grows exponentially, couple of indexing approaches have been proposed to speed up the identification of the sequences corresponding to the mass spectra. However, many of these approaches do not (or poorly) support interpretation of the spectra contaminated with posttranslational modifications (PTMs), which in real-world conditions occur very often. Wepropose a promising method for dealing with PTMs in mass spectra, including efficient similarity search employing metric indexing. In this paper, we generalize a previously proposed method based on the parametrized Hausdorff distance.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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