4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F11%3A10107370" target="_blank" >RIV/00216208:11320/11:10107370 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/11:00369807
Result on the web
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2011/OB/c1ob06148h" target="_blank" >http://pubs.rsc.org/en/Content/ArticleLanding/2011/OB/c1ob06148h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C1OB06148H" target="_blank" >10.1039/C1OB06148H</a>

Result language
angličtina
Original language name
4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics
Original language description
4'-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4'-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4'-methoxy or 4'-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2'-O-methyl-oligothymidylate. The 4'-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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