Formation and disruption of tonotopy in a large-scale model of the auditory cortex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10313779" target="_blank" >RIV/00216208:11320/15:10313779 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00452407

Result on the web

<a href="http://dx.doi.org/10.1007/s10827-015-0568-2" target="_blank" >http://dx.doi.org/10.1007/s10827-015-0568-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10827-015-0568-2" target="_blank" >10.1007/s10827-015-0568-2</a>

Result language

angličtina

Original language name

Formation and disruption of tonotopy in a large-scale model of the auditory cortex

Original language description

There is ample experimental evidence describing changes of tonotopic organisation in the auditory cortex due to environmental factors. In order to uncover the underlying mechanisms, we designed a large-scale computational model of the auditory cortex. The model has up to 100 000 Izhikevich's spiking neurons of 17 different types, almost 21 million synapses, which are evolved according to Spike-Timing-Dependent Plasticity (STDP) and have an architecture akin to existing observations. Validation of the model revealed alternating synchronised/desynchronised states and different modes of oscillatory activity. We provide insight into these phenomena via analysing the activity of neuronal subtypes and testing different causal interventions into the simulation. Our model is able to produce experimental predictions on a cell type basis. To study the influence of environmental factors on the tonotopy, different types of auditory stimulations during the evolution of the network were modelled and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/GAP303%2F12%2F1347" target="_blank" >GAP303/12/1347: Mechanisms underlying complex sound processing in the neuronal assemblies in the auditory system</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Computational Neuroscience

ISSN

0929-5313

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

23

Pages from-to

131-153

UT code for WoS article

000361467700003

EID of the result in the Scopus database

2-s2.0-84941935633