Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493479" target="_blank" >RIV/68378041:_____/18:00493479 - isvavai.cz</a>
Alternative codes found
RIV/71226401:_____/18:N0100112
Result on the web
<a href="http://dx.doi.org/10.1155/2018/5903720" target="_blank" >http://dx.doi.org/10.1155/2018/5903720</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2018/5903720" target="_blank" >10.1155/2018/5903720</a>

Result language
angličtina
Original language name
Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat
Original language description
It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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