The influence of developmental noise exposure on the temporal processing of acoustical signals in the auditory cortex of rats

Result code in IS VaVaI

RIV/68378041:_____/21:00551103 - isvavai.cz

Alternative codes found

RIV/68407700:21460/21:00353358 RIV/68407700:21730/21:00353358

Result on the web

https://onlinelibrary.wiley.com/doi/10.1002/ijc.33750

DOI - Digital Object Identifier

10.1016/j.heares.2021.108306

Result language

angličtina

Original language name

The influence of developmental noise exposure on the temporal processing of acoustical signals in the auditory cortex of rats

Original language description

Previous experiments have acknowledged that inappropriate or missing auditory inputs during the critical period of development cause permanent changes of the structure and function of the auditory system (Bures et al., 2017). We explore in this study how developmental noise exposure influences the coding of temporally structured stimuli in the neurons of the primary auditory cortex (AC) in Long Evans rats. The animals were exposed on postnatal day 14 (P14) for 12 minutes to a loud (125 dB SPL) broad-band noise. The responses to an amplitude-modulated (AM) noise, frequency-modulated (FM) tones, and click trains, were recorded from the right AC of rats of two age groups: young-adult (ca. 6 months old) and adult (ca. 2 years old), both in the exposed animals and in control unexposed rats. The neonatal exposure resulted in a higher synchronization ability (phase-locking) of the AC neurons for all three stimuli, furthermore, the similarity of neuronal response patterns to repetitive stimulation was higher in the exposed rats. On the other hand, the exposed animals showed a steeper decline of modulation-transfer functions towards higher modulation frequencies/repetition rates. Differences between the two age groups were also apparent, in general, aging had qualitatively the same effect as the developmental exposure. The current results demonstrate that brief noise exposure during the maturation of the auditory system influences both the temporal and the rate coding of periodically modulated sounds in the AC of rats, the changes are permanent and observable up to late adulthood.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

LTAIN19201: Processing of complex acoustical signals including vocalizations in inhibitory circuits of the central auditory system in mice models of autism and different types of sensorineural hearing loss.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hearing Research

ISSN

0378-5955

e-ISSN

1878-5891

Volume of the periodical

409

Issue of the periodical within the volume

sep.

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

108306

UT code for WoS article

000691603700013

EID of the result in the Scopus database

2-s2.0-85111032042