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A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405718" target="_blank" >RIV/00216208:11320/19:10405718 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KWszAH.q5P" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KWszAH.q5P</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/anie.201900682" target="_blank" >10.1002/anie.201900682</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions

  • Original language description

    Due to their high kinetic inertness and consequently reduced side reactions with biomolecules, Pt-IV complexes are considered to define the future of anticancer platinum drugs. The aqueous stability of a series of biscarboxylato Pt-IV complexes was studied under physiologically relevant conditions. Unexpectedly and in contrast to the current chemical understanding, especially oxaliplatin and satraplatin complexes underwent fast hydrolysis in equatorial position (even in cell culture medium and serum). Notably, the resulting hydrolysis products strongly differ in their reduction kinetics, a crucial parameter for the activation of Pt-IV drugs, which also changes the anticancer potential of the compounds in cell culture. The discovery that intact Pt-IV complexes can hydrolyze at equatorial position contradicts the dogma on the general kinetic inertness of Pt-IV compounds and needs to be considered in the screening and design for novel platinum-based anticancer drugs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

Result continuities

  • Project

    <a href="/en/project/GA16-06240S" target="_blank" >GA16-06240S: Structure and dynamics of organometallic complexes in bio-environment.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Angewandte Chemie - International Edition

  • ISSN

    1433-7851

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    22

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    6

  • Pages from-to

    7464-7469

  • UT code for WoS article

    000474803100051

  • EID of the result in the Scopus database

    2-s2.0-85065024407