A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405718" target="_blank" >RIV/00216208:11320/19:10405718 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KWszAH.q5P" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KWszAH.q5P</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201900682" target="_blank" >10.1002/anie.201900682</a>
Alternative languages
Result language
angličtina
Original language name
A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions
Original language description
Due to their high kinetic inertness and consequently reduced side reactions with biomolecules, Pt-IV complexes are considered to define the future of anticancer platinum drugs. The aqueous stability of a series of biscarboxylato Pt-IV complexes was studied under physiologically relevant conditions. Unexpectedly and in contrast to the current chemical understanding, especially oxaliplatin and satraplatin complexes underwent fast hydrolysis in equatorial position (even in cell culture medium and serum). Notably, the resulting hydrolysis products strongly differ in their reduction kinetics, a crucial parameter for the activation of Pt-IV drugs, which also changes the anticancer potential of the compounds in cell culture. The discovery that intact Pt-IV complexes can hydrolyze at equatorial position contradicts the dogma on the general kinetic inertness of Pt-IV compounds and needs to be considered in the screening and design for novel platinum-based anticancer drugs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)
Result continuities
Project
<a href="/en/project/GA16-06240S" target="_blank" >GA16-06240S: Structure and dynamics of organometallic complexes in bio-environment.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
22
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
7464-7469
UT code for WoS article
000474803100051
EID of the result in the Scopus database
2-s2.0-85065024407