Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00376804" target="_blank" >RIV/68081707:_____/12:00376804 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/tx200525n" target="_blank" >http://dx.doi.org/10.1021/tx200525n</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/tx200525n" target="_blank" >10.1021/tx200525n</a>

Result language
angličtina
Original language name
Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues
Original language description
The cellular and molecular pharmacology of the new class of anticancer drugs, in which CDK inhibitor bohemine and its analogues are coordinated to Pt(II) to form cisplatin derivatives, was investigated. The results revealed the unique anticancer profileof a cisplatin-derived platinum(II) dichlorido complex involving N(7)-coordinated bohemine (C1). The results also showed that the distinct differences in cell killing observed for C1 and cisplatin might be associated with processes at the DNA level. It was concluded that C1 remains a promising prototype of compounds for the generation of novel drug candidates with cytotoxicity profiles different from those of platinum drugs currently in use.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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