Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471974" target="_blank" >RIV/68081707:_____/16:00471974 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/16:33160052 RIV/00216305:26310/16:PU118030

Result on the web

<a href="http://dx.doi.org/10.1002/chem.201504671" target="_blank" >http://dx.doi.org/10.1002/chem.201504671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.201504671" target="_blank" >10.1002/chem.201504671</a>

Result language

angličtina

Original language name

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

Original language description

Anticancer therapy by platinum complexes, based on nanocarrier-based delivery, may offer a new approach to improve the efficacy and tolerability of the platinum family of anticancer drugs. The original rules for the design of new anticancer platinum drugs were affected by the fact that, although cisplatin (cis-[PtCl2(NH3)(2)) was an anticancer drug, its isomer transplatin was not cytotoxic. For the first time, it is demonstrated that simple encapsulation of an inactive platinum compound in phospholipid bilayers transforms it into an efficient cytotoxic agent. Notably, the encapsulation of transplatin makes it possible to overcome the resistance mechanisms operating in cancer cells treated with cisplatin and prevents inactivation of transplatin in the extracellular environment. It is also shown that transplatin delivered to the cells in nanocapsules, in contrast to free (nonencapsulated) complex, forms cytotoxic cross-links on DNA.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

2728-2735

UT code for WoS article

000370193000022

EID of the result in the Scopus database

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