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Sonochemical Formation of Copper/Iron-Modified Graphene Oxide Nanocomposites for Ketorolac Delivery

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405812" target="_blank" >RIV/00216208:11320/19:10405812 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=57QZevx9h" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=57QZevx9h</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/chem.201900662" target="_blank" >10.1002/chem.201900662</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Sonochemical Formation of Copper/Iron-Modified Graphene Oxide Nanocomposites for Ketorolac Delivery

  • Original language description

    A feasible sonochemical approach is described for the preparation of copper/iron-modified graphene oxide nanocomposites through ultrasonication (20 kHz, 18 W cm(-2)) of an aqueous solution containing copper and iron ion precursors. Unique copper-, copper/iron- and iron-modified graphene oxide nanocomposites have a submicron size that is smaller than that of pristine GO and a higher surface area enriched with Cu2O, CuO, and Fe2O3 of multiform phases (alpha-, beta-, epsilon-, or gamma), FeO(OH), and sulfur- or carbon-containing compounds. These nanocomposites are sonochemically intercalated with the nonsteroidal anti-inflammatory drug ketorolac, which results in the formation of nanoscale carriers. Ketorolac monotonically disintegrates from these nanoscale carriers in aqueous solution upon adjustment of the pH from 1 to 8. The disintegration of ketorolac proceeds at a slower rate from the copper/iron-modified graphene oxide at increased pH, but at a faster rate from the iron-modified graphene oxide under acidic conditions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10305 - Fluids and plasma physics (including surface physics)

Result continuities

  • Project

    <a href="/en/project/LM2015057" target="_blank" >LM2015057: Surface Physics Laboratory – Materials Science Beamline</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chemistry - A European Journal

  • ISSN

    0947-6539

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    24

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    13

  • Pages from-to

    6233-6245

  • UT code for WoS article

    000467185100025

  • EID of the result in the Scopus database

    2-s2.0-85063936783