Dynamical Synergy of Drug Combinations during Cancer Chemotherapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F22%3A10456029" target="_blank" >RIV/00216208:11320/22:10456029 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D1jwGbQuuU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D1jwGbQuuU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jpm12111873" target="_blank" >10.3390/jpm12111873</a>

Result language
angličtina
Original language name
Dynamical Synergy of Drug Combinations during Cancer Chemotherapy
Original language description
Synergistic drug combinations often provide effective strategies to increase treatment efficacy and, during therapy, it is a time-dependent process. Data for colorectal and lung cancer in vivo were used for the phenomenological study of dynamical synergy during treatments. The proposed approach takes into consideration tumor regrowth by macroscopic laws. The time dependencies of synergistic drug combinations are analyzed by different parametric indicators. The cumulative effects of the single therapy and drug combinations are quantitatively well described and related to the cumulative doses. In conclusion, the analysis of dynamical synergy during chemotherapy has to take into account the effects of the drug doses and the tumor regrowth, which can provide a reliable description of the synergistic time dependence.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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