Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F23%3A10474639" target="_blank" >RIV/00216208:11320/23:10474639 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=s4J_lt~eYl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=s4J_lt~eYl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bpj.2023.10.002" target="_blank" >10.1016/j.bpj.2023.10.002</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin
Original language description
Mammalian and Drosophila melanogaster model mitochondrial membrane compositions are constructed from experimental data. Simplified compositions for inner and outer mitochondrial membranes are provided, including an asymmetric inner mitochondrial membrane. We performed atomistic molecular dynamics simulations of these membranes and computed their material properties. When comparing these properties to those obtained by extrapolation from their constituting lipids, we find good overall agreement. Finally, we analyzed the curvature effect of cardiolipin, considering ion concentration effects, oxidation, and pH. We draw the conclusion that cardiolipin-negative curvature is most likely due to counterion effects, such as cation adsorption, in particular of H3O thorn . This oft-neglected effect might account for the puzzling behavior of this lipid.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10102 - Applied mathematics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biophysical Journal
ISSN
0006-3495
e-ISSN
1542-0086
Volume of the periodical
122
Issue of the periodical within the volume
21
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
4274-4287
UT code for WoS article
001108963200001
EID of the result in the Scopus database
2-s2.0-85174457874