Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F25%3A10510603" target="_blank" >RIV/00216208:11320/25:10510603 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9tSwNmT2cE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9tSwNmT2cE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5tb01774b" target="_blank" >10.1039/d5tb01774b</a>

Result language

angličtina

Original language name

Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation

Original language description

Poly(1,2,3-triazole)-based polymers remain underexplored as a versatile platform for biomedical soft materials. Here, we report the modular synthesis of amphiphilic poly(1,2,3-triazole)-co-polytriazolium copolymers (qH-PETH) via copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) polyaddition and post-polymerization quaternization with a degree of quaternization equal to (0.85). These polymers exhibit unusual visible colouration in the absence of chromophores-appearing almost colourless in N-methyl-2-pyrrolidone (NMP), orange in DMSO, and pale orange in water-accompanied by a pronounced red shift in non-polar solvents such as dichloromethane (DCM) or chloroform. This optical behaviour is attributed to solvent-dependent supramolecular aggregation. Dynamic light scattering (DLS) measurements reveal hydrodynamic diameters of &lt;20 nm in water and approximately 500 nm in chloroform for quaternized polymers (qH-PETH), indicating strong aggregation in low-polarity environments. UV-vis spectroscopy and atomic force microscopy (AFM) further support aggregation-induced optical effects modulated by solvent polarity and hydrogen-bonding capacity. Both neutral and quaternized polymers display excellent cytocompatibility toward human cell lines (HeLa, HEK293, THP-1) at concentrations up to 100 mu g mL(-1), with no detectable immunogenic activation. These findings position poly(1,2,3-triazole)-co-polytriazolium copolymers as a promising, tunable class of biocompatible soft materials for biointerface engineering and responsive biomedical applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10305 - Fluids and plasma physics (including surface physics)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

2050-7518

Volume of the periodical

13

Issue of the periodical within the volume

40

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

12895-12902

UT code for WoS article

001585868600001

EID of the result in the Scopus database

2-s2.0-105018679886