Effect of Creatine Applied as Food Supplement on Human Metabolism

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F10%3A10071295" target="_blank" >RIV/00216208:11510/10:10071295 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of Creatine Applied as Food Supplement on Human Metabolism
Original language description
Creatine (CR), is recommended for application as food supplement. It is supposed that human organism uses it for formation of CR phosphate as source of energy. In our short-term experiments we have observed changes in the metabolism of two-carbon (2C) units and of thiolic substances 4 to 6 hours after CR supplementation. The level of thiodiglycolic acid (TDGA) in urine increased rapidly and then decreased again to the original level. The level of TDGA in urine is a marker of disturbance in metabolic pathways of 2C units and of thiolic compounds. Our long-term CR supplementation, revealed that the biochemical pathways, affected by CR application included intrinsic participation of vitamin B12 and folates. The levels of those two vitamins changed in a mutually reverse way. The men under study can be divided into 4 different groups according to changes of CR levels found in urine, and of levels of folates and vitamin B12, determined in blood before and after CR administration.
Czech name
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Czech description
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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