The dysregulation of monocyte subpopulations in individuals at risk of developing rheumatoid arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F21%3A10428540" target="_blank" >RIV/00216208:11510/21:10428540 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/21:N0000074 RIV/00216208:11110/21:10428540

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GhIwFWUekE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GhIwFWUekE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rheumatology/keaa518" target="_blank" >10.1093/rheumatology/keaa518</a>

Result language

angličtina

Original language name

The dysregulation of monocyte subpopulations in individuals at risk of developing rheumatoid arthritis

Original language description

Objectives. Individuals carrying antibodies against citrullinated proteins (ACPA) are at high risk of developing RA. EULAR provided a clinical definition of individuals with arthralgia suspicious for progression to RA (clinically suspect arthralgia, CSA). The alteration of monocyte subpopulations in patients with established RA has been previously described. We analysed peripheral blood monocyte subpopulations in individuals with arthralgia at risk of RA. Methods. We included 70 at-risk individuals, defined as having arthralgia without arthritis and being either ACPA(+) or meeting the clinical CSA definition, 23 patients with early RA (ERA) and 19 healthy controls (HCs). Monocytes classified as classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+/++)) and nonclassical (CD14(-/+)CD16(++)) were analysed by flow cytometry. Results. Of the 70 at-risk individuals, 46 were ACPA(+) and 45 met the CSA definition. The at-risk individuals and, especially, ERA patients had a lower percentage of classical monocytes and a higher percentage of nonclassical monocytes than the HCs. ACPA positivity had no effect on the difference in the distribution of the monocyte subsets between at-risk individuals and ERA patients, but a difference was determined in those reaching the ERA phase. However, when compared with HCs, the shift of monocyte subsets was more significant in ACPA(+) than in ACPA(-) individuals with arthralgia. This trend was observed in individuals who did not meet the CSA definition. This finding was, however, determined by a selection bias, as these individuals were solely ACPA(+). Conclusion. The shift from classical to nonclassical monocyte subpopulations was observed already in individuals at risk of developing RA.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV17-32612A" target="_blank" >NV17-32612A: Clinically suspect arhralgia: characteristics of the preclinical phase of rheumatoid arthritis</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Rheumatology

ISSN

1462-0324

e-ISSN

—

Volume of the periodical

60

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1823-1831

UT code for WoS article

000644544400044

EID of the result in the Scopus database

2-s2.0-85104048166