Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00002245" target="_blank" >RIV/00216224:14110/00:00002245 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations

Original language description

Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients pretreated with CYP2D6 substrate drugs that within those without previous therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Psychopharmacol.

ISSN

0885-6222

e-ISSN

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Volume of the periodical

2000

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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