Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008962" target="_blank" >RIV/00216224:14110/03:00008962 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

Original language description

Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation ofthe paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemické listy

ISSN

0009-2770

e-ISSN

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Volume of the periodical

97 (S)

Issue of the periodical within the volume

červen

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

"S180"

UT code for WoS article

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EID of the result in the Scopus database

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