Dynamics and persistence of CYP2D6 inhibition by paroxetine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065968" target="_blank" >RIV/00216224:14740/13:00065968 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002090
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12042/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12042/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcpt.12042" target="_blank" >10.1111/jcpt.12042</a>

Result language
angličtina
Original language name
Dynamics and persistence of CYP2D6 inhibition by paroxetine
Original language description
What is known and Objective Paroxetine is both a substrate and an inhibitor of CYP2D6. The objective of the presented study was to determine the persistence of CYP2D6 inhibition after short term (6 weeks) and long term (18,7 +/- 10,6 weeks) paroxetine treatment. Methods: Two the studies consisted of 30 depressive/anxiety patients each. In the first study, patients were subdivided into three groups treated with paroxetine (A1), alprazolam (A2) and paroxetine + alprazolam (A3). After 6 weeks, all the patients (A1+A2+A3) were switched to alprazolam treatment; metabolic activity was evaluated at the beginning, after 6 weeks of paroxetine/alprazolam/alprazolam + paroxetine treatment (A1/A2/A3) and 4 weeks after the switch to alprazolam treatment (Week 0, 6,10). In the second study patients on previous long term paroxetine treatment were subdivided into two groups treated with mirtazapine (B1) or paroxetine (B2); metabolic activity of CYP2D6 was evaluated at the beginning and after 6 weeks
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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