An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00002557" target="_blank" >RIV/00216224:14110/00:00002557 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension

Original language description

Four hundred of Caucasian (Czech) normotensive (normotension was confirmed by 24-h ambulatory blood pressure monitoring) and hypertensive subjects of the age of 45-55 years were compared in three ET-1 gene (6p21.3) polymorphisms CA/CT dinucleotide repeatin Z-area, I/D (-4A/-3A) polymorphism in the promoter and Taq1 (G8002A) polymorphism in the intron 4 detected by PCR methods.The allelic length of CA/CT dinucleotide repeat polymorphism was significantly higher in hypertensive subjects (P=0.032). Allelic concurrence of I/D promoter polymorphism and Taq1 polymorphism was significantly different (P=0.008) in hypertensive vs.normotensive women (not in men). Linkage disequilibria between CA/CT and Taq polymorphisms were found both in hypertensive (P=0.008)and normotensive (P=0.02) subjects. Complex interaction among alleles inside the gene coding for ET-1 gene could participate in pathogenesis of essential hypertension.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Atherosclerosis

ISSN

0021-9150

e-ISSN

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Volume of the periodical

151

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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