Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005720" target="_blank" >RIV/00216224:14110/02:00005720 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.

Original language description

The aim of the study is to evaluate association of three endothelin-1 (ET-1) gene polymorphisms with the essential hypertension as well as with two risk cardiovascular factors- BMI and smoking. Three gene polymorphisms and the genotype and/or allelic distributions were compared between normotensive healthy volunteers and patients with essential hypertension. Genetic association of the three genotypes with BMI and smoking status was calculated. CA/CT dinucleotide repeat polymorphism, the G (8002) A polymorphism and 3A/-4A polymorphism (-138 insertion/ deletion) in the gene coding for endothelin-1 (ET-1, 6p21.3) in 398 subjects, 192 normotensives (healthy volunteers) and 206 patients with essential hypertension. The normotension was verified by 24-h ambulatory blood pressure monitoring (ABPM, SpaceLab 90 207). Significant inner associations were observed among all three polymophisms, which suggests possible complex interaction inside the gene. The only significant difference in single ge

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Clinical Cardiology

ISSN

xxxxxx

e-ISSN

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Volume of the periodical

2002

Issue of the periodical within the volume

xx

Country of publishing house

CA - CANADA

Number of pages

5

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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