Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00002736" target="_blank" >RIV/00216224:14110/00:00002736 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis

Original language description

This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003).

Czech name

Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Dermatological Research

ISSN

0340-3696

e-ISSN

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Volume of the periodical

292

Issue of the periodical within the volume

11

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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