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Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069381" target="_blank" >RIV/00216224:14110/13:00069381 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/13:#0002071 RIV/00159816:_____/13:00060658

  • Result on the web

    <a href="http://dx.doi.org/10.1111/ijd.12213" target="_blank" >http://dx.doi.org/10.1111/ijd.12213</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/ijd.12213" target="_blank" >10.1111/ijd.12213</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

  • Original language description

    Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FO - Dermatology and venereology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Dermatology

  • ISSN

    0011-9059

  • e-ISSN

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    960-965

  • UT code for WoS article

    000322015000009

  • EID of the result in the Scopus database