Interaction of five gene polymorphism at psoriasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F99%3A00002134" target="_blank" >RIV/00216224:14110/99:00002134 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Interaction of five gene polymorphism at psoriasis
Original language description
Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009)but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FO - Dermatology and venereology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
1999
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Investigative Dermatology
ISSN
0022-202X
e-ISSN
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Volume of the periodical
1999
Issue of the periodical within the volume
113
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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