IgA deficiency in Czech healthy individuals and selected patient groups

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003660" target="_blank" >RIV/00216224:14110/00:00003660 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

IgA deficiency in Czech healthy individuals and selected patient groups

Original language description

Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level &lt; 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P&lt;0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients.

Czech name

IgA deficincy in Czech healthy individuals and selected patient groups

Czech description

VMezi dárci krve v ČR se vyskytuje IgAD ve frekvenci 1:408.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NI4703" target="_blank" >NI4703: Immunoregulatory defects in patients with humoral immunodeficiencies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Int Arch Allergy Immunol

ISSN

1018-2438

e-ISSN

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Volume of the periodical

123

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

4

Pages from-to

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UT code for WoS article

000165180100011

EID of the result in the Scopus database

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