B-lymphocyte Subpopulations in Patients with Selective IgA Deficiency
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059958" target="_blank" >RIV/00216224:14110/12:00059958 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/12:#0000817
Result on the web
<a href="http://dx.doi.org/10.1007/s10875-012-9655-6" target="_blank" >http://dx.doi.org/10.1007/s10875-012-9655-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10875-012-9655-6" target="_blank" >10.1007/s10875-012-9655-6</a>
Alternative languages
Result language
angličtina
Original language name
B-lymphocyte Subpopulations in Patients with Selective IgA Deficiency
Original language description
Selective deficiency IgA (IgAD) is the most common primary abnormality of immunoglobulin production with unknown pathophysiology. It is genetically related to common variable immunodeficiency (CVID), where besides IgA also IgG and frequently IgM serum levels are decreased. In this study we focused on determination of B-lymphocyte developmental stages and searching for similarities between CVID and IgAD. Materials and Methods Using flow cytometry we determined major lymphocyte subpopulations and Blymphocyte subsets: naive (CD27-IgD+), marginal zone cells (CD27+IgD+), class-switched memory cells (CD27+IgD-), ?double-negative? B cells (CD27-IgD-), transitional cells (IgM++CD38++), plasmablasts (CD38+++IgM+ or IgM-), and CD21lowCD38low cells in 80 patientswith IgAD, 48 patients with CVID, and 80 control persons. Results Compared to healthy controls, a decrease in the absolute number and frequency of CD4+ cells (both<0.001) was observed in IgAD patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10398" target="_blank" >NS10398: Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Immunology
ISSN
0271-9142
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
441-448
UT code for WoS article
000305982100005
EID of the result in the Scopus database
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