T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019151" target="_blank" >RIV/00216224:14110/07:00019151 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/07:#0000361
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency
Original language description
Selective deficiency of immunoglobulin A (IgAD) and common variable immunodeficiency (CVID) are genetically closely related diseases, both of unknown pathogenesis. A plethora of abnormalities in lymphocyte subpopulations and expression of activation markers were repeatedly documented in CVID patients, while almost no data are available about lymphocyte subpopulations in IgAD patients. We determined basic lymphocyte subpopulations and those subpopulations that were reported to be abnormal in CVID patients (CD25, human leucocyte antigen (HLA)-DR CD45RA, CD45RO, CD27, CD28 and CD29 on both CD4(+) and CD8(+) cells, CD57 and CD38 on CD8(+) cells, CD21, CD27, IgM, IgD on B lymphocytes) in 85 patients with IgAD, 47 patients with CVID and in 65 healthy controls. Statistical analysis was performed by the Mann-Whitney U-test; significant P-values were determined by means of Bonferoni's correction. Our results showed an increase in the relative number of CD8(+) cells and a decrease in the absolut
Czech name
T- a B- lymfocytární subpopulace a aktivační/diferenciační znaky u nemocných se selektivní deficitem IgA
Czech description
Byly měřeny aktivační a diferenciační znaky T-a B-lymfocytů u nemocných s IgAD a byla srovnány s nemocnými s CVID a s normálními osobami.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/NR7981" target="_blank" >NR7981: Lymphocyte subpopulatins in patients with humoral immunodeficiencies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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