Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067727" target="_blank" >RIV/00159816:_____/17:00067727 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00095689

Result on the web

<a href="https://www.termedia.pl/Terminally-differentiated-memory-T-cells-are-increased-in-patients-with-common-variable-immunodeficiency-and-selective-IgA-deficiency,10,30868,1,1.html" target="_blank" >https://www.termedia.pl/Terminally-differentiated-memory-T-cells-are-increased-in-patients-with-common-variable-immunodeficiency-and-selective-IgA-deficiency,10,30868,1,1.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/ceji.2017.70966" target="_blank" >10.5114/ceji.2017.70966</a>

Result language

angličtina

Original language name

Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Original language description

Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Immunology

ISSN

1426-3912

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

244-251

UT code for WoS article

000415131100004

EID of the result in the Scopus database

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