Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00018865" target="_blank" >RIV/00216224:14110/06:00018865 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/06:#0000028

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients

Original language description

Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development weredetermined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29,HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. The expression of CD27 and CD45RA on CD4+ T-lymphocytes, such as the percen

Czech name

Vliv věku a vzájemné vztahy mezi abnormalitami T- a B- lymfocytů u běžného variabilního imunodeficitu

Czech description

Byly sledovány vztahy mezi abnormalitami počtů lymfocytárních subpopulací a expresí různých aktivačních a diferencičních znaků u pacientů s běžným variabilním imunodeficitem (CVID) a u kontrolních osob. Byl též prokáznán vliv věku pacientů na expresi antigenů CD45RA na CD4+ buněkách, stejně jako na některé B-lymfocytární subpopulace.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

<a href="/en/project/NR7981" target="_blank" >NR7981: Lymphocyte subpopulatins in patients with humoral immunodeficiencies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clin Exp Immunol

ISSN

0009-9104

e-ISSN

—

Volume of the periodical

143

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

373-379

UT code for WoS article

—

EID of the result in the Scopus database

—