Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00002752" target="_blank" >RIV/00216224:14110/01:00002752 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

Original language description

The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<1*10-6 and P=1*10-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/VS96097" target="_blank" >VS96097: Molecular pathophysiology of selected multigenic related to civilization diseases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ophthalmologica

ISSN

0030-3755

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

215

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

294

UT code for WoS article

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EID of the result in the Scopus database

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