Polymorphisms in the von Willebrand factor gene are not associated with proliferative retinopathy in NIDDM

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006123" target="_blank" >RIV/00216224:14110/02:00006123 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polymorphisms in the von Willebrand factor gene are not associated with proliferative retinopathy in NIDDM

Original language description

Von Willebrand factor, a multimeric glycoprotein synthesised mainly by endothelial cells, is involved in platelet adhesion and aggregation and performs an important role in the process of angiogenesis. Increased levels of von Willebrand factor, reflecting activation or damage of endothelial cells, have been described in association with proliferative diabetic retinopathy (PDR). We investigated the relationships of two polymorphisms (-1793G/C and Thr789Ala) in the von Willebrand factor gene with PDR. Genotypes were detected by polymerase chain reactions with subsequent restrictions with specific endonucleases. Allele frequencies were determined in an association study (n=371) comprising three groups of subjects (diabetics with and without retinopathy and non-diabetics). Allele frequencies of the -1793G/C and Thr789Ala did not differ between the NIDDM+PDR and the NIDDM non-PDR groups (P>0.05). However, a statistically significant difference in allele and genotype frequencies of the -1793

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ophthalmic Research

ISSN

0030-3747

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

4

Pages from-to

327

UT code for WoS article

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EID of the result in the Scopus database

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