New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004264" target="_blank" >RIV/00216224:14110/01:00004264 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/01:00004974
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
Original language description
A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA303%2F00%2FD062" target="_blank" >GA303/00/D062: Bioavailability and mechanism of antioxidant activity of phenolic acids and lignans</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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