MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004265" target="_blank" >RIV/00216224:14110/01:00004265 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS
Original language description
The polyphenolic compound 1, also known as cynarin, is of interest biomedically because of its hypocholesterolemic, hepatoprotective and antioxidant activity.1 The dicaffeoylquinic acids (DCQAs), in general, show a number of pharmacological actions, withthe most important being anti-HIV activity. The DCQAs have recently been recognized as an important class of HIV-integrase inhibitors and, thus, prevent insertion of viral DNA into the host genome, and essential step in the replication of the virus. TheDCQAs strongly and irreversibly inhibit HIV-1 integration in biochemical assays and block viral replication at non-toxic concentrations. Earlier studies2 showed that the peracetate derivatives of 3 and 4 displayed greater anti-HIV activity than the freecompounds and that the activity of peracetyl-3 approaches that of AZT. Thus, there is considerable biomedical interest in the DCQAs and selected derivatives of the DCQAs. Obtaining quantities of pure 1 has been difficult. Extraction from
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F00%2FD062" target="_blank" >GA303/00/D062: Bioavailability and mechanism of antioxidant activity of phenolic acids and lignans</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
49th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics
ISBN
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ISSN
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e-ISSN
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Number of pages
2
Pages from-to
67
Publisher name
American Society for Mass Spectrometry
Place of publication
Chicago
Event location
Chicago
Event date
Jan 1, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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