Polymorphism 2184A/G in the gene encoding Receptor of Advanced Glycation End products (RAGE) is a newly identified risk factor for diabetic nephropathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006122" target="_blank" >RIV/00216224:14110/02:00006122 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Polymorphism 2184A/G in the gene encoding Receptor of Advanced Glycation End products (RAGE) is a newly identified risk factor for diabetic nephropathy
Original language description
Association of the genetic polymorphism in the Receptor of Advanced Glycation End products (RAGE) gene with diabetic nephropathy (DN) in patients with both type 1 and 2 diabetes mellitus was studied. Significant difference in allele frequencies of the 2184A/G between ESRD subgroup and non-DN group was found (P=0.021, Fisher exact test. Moreover, marginally significant association of allele D with DN was detected for the I/D ACE polymorphism (P= 0.075). The presented data indicate that the 2184A/G polymorphism in the RAGE gene could be regarded as one of genetic risk factors for DN. Association of this polymorphism with susceptibility to develop DN and rate of progression and severity of DN is a subject of ongoing study.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetologia
ISSN
0012-186X
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
suppl 2
Country of publishing house
AT - AUSTRIA
Number of pages
1
Pages from-to
358
UT code for WoS article
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EID of the result in the Scopus database
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