Relationship between genetic polymorphisms within the pro-oxidant/antioxidant systems and diabetic nephropathy - preliminary results
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008084" target="_blank" >RIV/00216224:14110/03:00008084 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Relationship between genetic polymorphisms within the pro-oxidant/antioxidant systems and diabetic nephropathy - preliminary results
Original language description
Background and Aims: Association of selected genetic polymorphisms in genes encoding for glyoxalase I (A111E GLYI), paraoxonase (R192Q and M55L PON), NAD(P)H: quinone oxidoreductase (P187S NQO1) and methylenetetrahydrofolate reductase (677C/T MTHFR) withdiabetic nephropathy (DN) in patients with both type 1 and type 2 diabetes mellitus was studied. Further, interactions of studied polymorphisms with previously associated polymorphism 2184A/G in the gene for receptor of advanced glycation end products (2184A/G RAGE) were investigated. Materials and Methods: A total of 318 Caucasian subjects was so far enrolled in the association study: diabetics with parallel DN (n=135, mean age 63.7) and diabetics without DN (n=183, mean age 64.5). DN group comprisedpatients with (i) persistent proteinuria, (ii) chronic renal failure and (iii) end-stage renal disease (ESRD) with regular hemodialysis. Allele frequencies of polymorphisms were determined by polymerase chain reaction based methodology. R
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP303%2F02%2FD127" target="_blank" >GP303/02/D127: Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetologia
ISSN
0012-186X
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
Suppl 2
Country of publishing house
DE - GERMANY
Number of pages
1
Pages from-to
"A336"
UT code for WoS article
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EID of the result in the Scopus database
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