Nucleolus and Apoptosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007251" target="_blank" >RIV/00216224:14110/02:00007251 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/02:00006147
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nucleolus and Apoptosis
Original language description
The nucleolus represents a highly dynamic nuclear compartment of the interphase nucleus. It plays a key role in ribosome biogenesis. The number of nucleoli, their size, and their activity increase in exponentially growing cells; therefore these parameters reflect the proliferating activity of the cells. Nucleolar changes and pleomorphism associated with overt proliferation of tumor cells have also been documented by immunohistochemical and ultrastructural studies. Contrary to cell proliferation, cytostatics-induced changes of nucleolar phenotype in malignant cells point to a potential role of nucleolar components in the execution of active cell death. It can be concluded that the plurifunctionality of nucleoli regarding cell proliferation and apoptosiscould open new vistas toward understanding dysregulation in malignant cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/NC6399" target="_blank" >NC6399: Analysis of apoptosis in cervical neoplasia.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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