Antidepressant-like effects of amisulpride in bubectomized male rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007505" target="_blank" >RIV/00216224:14110/02:00007505 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Antidepressant-like effects of amisulpride in bubectomized male rats
Original language description
Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Ratswith bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambul
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
66
Publisher name
Czech and Slovak Neurochemical Society
Place of publication
Častá, Slovakia
Event location
June 1-5, 2002 Častá, Slovakia
Event date
Jan 1, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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