Dominant negative ATM mutationsn in breast cancer families

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007646" target="_blank" >RIV/00216224:14110/02:00007646 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Dominant negative ATM mutationsn in breast cancer families
Original language description
Breast cancer is the most frequent malignancy in women in the world, with a cumulative lifetime risk estimated to be 10-12%. Cytogenic and molecular genetic analyses of breast tumor cells suggest that the development of human breast cancer involves the accumulation of alterations in genes which normally serve to control growth and differentiation. One type of this alteration is loss of heterozygosity (LOH), which is detected in many cases of breast cancer. LOH of tumor suppressor genes are associated with cancerogenesis. Several studies have indicated that the genes harbors on long arm of chromosome 11, could be detected during tumorogenesis. Deletions at 11q23 were detected in variety of human neoplasma, including breast. In this region can be harborat least one tumor suppressor gene, which is inactivated during the establishment or progression of several types of tumors. Evidence for the existence of a tumor suppresor gene(s) in this region came from the observation that tumorgenici
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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