Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008083" target="_blank" >RIV/00216224:14110/03:00008083 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications
Original language description
Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patientswith type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manif
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP303%2F02%2FD127" target="_blank" >GP303/02/D127: Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Stress, Signalling and Control
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
59
Publisher name
Biochemical Society
Place of publication
London, Great Britain
Event location
University of Essex, UK
Event date
Jan 1, 2003
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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