Antidepressive-like felbamate effects on exploratory behaviour in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00009515" target="_blank" >RIV/00216224:14110/03:00009515 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antidepressive-like felbamate effects on exploratory behaviour in mice

Original language description

The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinicallyused antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Homeostasis

ISSN

0960-7560

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

1-2

Country of publishing house

IT - ITALY

Number of pages

2

Pages from-to

92-93

UT code for WoS article

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EID of the result in the Scopus database

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