Behavioural effects of felbamate in the model of social interaction in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005697" target="_blank" >RIV/00216224:14110/02:00005697 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Behavioural effects of felbamate in the model of social interaction in mice

Original language description

Felbamate belongs to the antiepileptics of the third generation which are tested for their behavioural effects potentially useful particularly in depressive patients. The present study used the ethological model of agonistic behaviour based on the intra-species social conflict in male mice to investigate the effects of felbamate (15, 60 and 240 mg/kg, orally) on sociable, defensive-escape, aggressive and locomotor behaviour observed in singly-housed male mice during their social interactions with the non-aggressive group-housed male counterparts. In the aggressive mice felbamate produced a dose-dependent reduction in the behavioural score of aggressivity, significant after all doses tested. In the wide dosage interval of 15 - 240 mg/kg felbamate showedno sedative effect on locomotion, in addition, the ambulation was significantly disinhibited afte the dose of 15 mg/kg. The stimulatory effect of felbamate on locomotion was found also in the timid mice, significantly after the dose of 2

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Homeostasis

ISSN

0960-7560

e-ISSN

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Volume of the periodical

2001

Issue of the periodical within the volume

41

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

2

Pages from-to

137

UT code for WoS article

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EID of the result in the Scopus database

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