Changes of mouse agonistic behaviour induced by cannabinoid receptor agonist HU 210 and antagonist AM 251
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004404" target="_blank" >RIV/00216224:14110/01:00004404 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Changes of mouse agonistic behaviour induced by cannabinoid receptor agonist HU 210 and antagonist AM 251
Original language description
Cannabinoids are known to produce behavioural changes influencing on social interactions of the user. However, the experimental evidence in this field is rather poor. The present study investigated the influence of two cannabinoid receptor ligands on social behavioural acts in singly-housed male mice on dyadic agonistic interactions with the non-aggressive group-housed partners in neutral cages. The synthetic cannabinoid receptor agonist HU 210 caused a typical biphasic effects, low dose (0.01 mg/kg) produced stimulation of aggression in timid mice, while high doses (0.05 and 0.1 mg/kg) elicited inhibition. Cannabinoid receptor antagonist AM 251 (0.5 and 2.5 and 7.5 mg/kg) did not elicit any significant changes of the behaviour in aggressive mice, however acts pro-aggressively in timid mice.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Behavioural Pharmacology
ISSN
0955-8810
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
Suppl. 1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
107
UT code for WoS article
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EID of the result in the Scopus database
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