Cannabinoids: effects on behaviour and leukocyte phagocytosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007827" target="_blank" >RIV/00216224:14110/02:00007827 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cannabinoids: effects on behaviour and leukocyte phagocytosis
Original language description
The study shows that both agonistic and antagonistic manipulation with cannabinoid CB1 as well as CB2 receptor caused changes in social behaviour in mice. Mixed CB1,2 agonists produced biphasic effects - stimulation of aggressive behaviour in timid miceat low doses and inhibition of aggressive activities in aggressive mice at high doses. Inhibitory influence on aggressive behaviour in aggressive mice was present also after all tested doses of selective CB1 agonist, was lower after CB2 agonist and was not apparent after administration of CB1 antagonist. Pro-aggressive effects in timid mice were elicited besides CB1,2 agonists also by both, CB1 and CB2 agonist. The effects of cannabinoid receptor ligands on leukocyte phagocytosis resemble those observedin behavioural studies as CB1,2 agonists produced biphasic influence - stimulation and suppression of phagocytic activity at low and high doses, respectively. Such effects were apparent also after administration of selective CB2 agonist
Czech name
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Czech description
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy
ISBN
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ISSN
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e-ISSN
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Number of pages
3
Pages from-to
30-32
Publisher name
LF MU Brno
Place of publication
Brno
Event location
April 18 - 21, 2002, Brno, Czech Republic
Event date
Jan 1, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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