Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010247" target="_blank" >RIV/00216224:14110/04:00010247 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects.
Original language description
Impact of cannabinoid CB2 receptor activity on aggressive behavior in mice and sensitization to methamphetamine antiaggresive effects. Cannabinoid receptor CB2 is localized mainly outside of the CNS. Thus a poor impact of its activity on behavior can beexpected. Previously we found development of both sensitization to methamphetamine (MET) antiaggressive effects by pre-treatment with repeated MET doses and a cross-sensitization to this MET effect with cannabinoid CB1 receptor agonist methanandamide inthe model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners. This supported the evidence of interaction between the endocannabinoid system and MET brain mechanism. The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine. Therefore the CB2 receptor agonist JWH 015 (JWH) has been te
Czech name
Vliv aktivity kanabinoidních receptorů CB2 na agresivitu u myší a sensitizacei k antiagresivnímu účinku metamfetaminu
Czech description
Na rozdíl od dříve prezentovaných výsledků sledujících stejné vzatahy při farmakologikcém ovlivňování kanabinoidních receptorů CB1,stimulace CB2 receptorů nevedla ke krossensitizaci k antiagresivním účinkům metamfetaminu.
Classification
Type
A - Audiovisual production
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
ISBN
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Place of publication
Portugalsko
Publisher/client name
FENS
Version
CD - FENS Forum 2004
Carrier ID
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