Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00009585" target="_blank" >RIV/00216224:14110/03:00009585 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/03:51030119 RIV/00216224:14110/03:00008682
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.
Original language description
In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.
Czech name
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Czech description
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Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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