Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F10%3A00351844" target="_blank" >RIV/61388998:_____/10:00351844 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

Original language description

A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Analysis of biomedical signals and images

ISBN

978-80-214-4106-4

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

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Publisher name

University of technology

Place of publication

Brno

Event location

Brno

Event date

Jun 27, 2010

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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