Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015543" target="_blank" >RIV/00216224:14110/06:00015543 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study

Original language description

To explore the physiological consequences of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea-pig cardiac ventricular myocytes, we have developed mathematical models of their electrical activity that include a quantitative description of the TATS. In both models, transient depletion of tubular Ca2+ occurred during each action potential and decreased intracellular Ca2+ load and consequently systolic Ca2+ transient amplitude. However, the magnitude of this effect and its frequency dependence was different in the two species.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů