The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010402" target="_blank" >RIV/00216224:14110/04:00010402 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.
Original language description
Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field.
Czech name
Vliv felbamátu na rozvoj sensitizace k behaviorálním účinkům metamfetqaminu u myší
Czech description
Výsledky potvrdily preventivní efekt felbamátu k expresi sensitizace k behaviorálním účinkům dávky metafetaminu po dané po vysazení opakového podávání této drogy.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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